cytopathic – Communicable Diseases Research

Identification and characterization of the anti-SARS-CoV-2 activity of cationic amphiphilic steroidal compounds

양이온성 양친매성 스테로이드 화합물의 항 SARS-CoV-2 활성의 확인 및 특성화

Article

Published on 2022-12-012022-09-11
Journal: Virulence
[Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

Persistent Antibody Responses Up to 18 Months After Mild Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Article

Published on 2022-09-282022-11-15
Journal: The Journal of Infectious Diseases
[Category] SARS, 변종, 진단, 치료기술,

[키워드] acute respiratory syndrome Antibody Response Antibody titer B.1.1.529 B.1.1.7 B.1.167.2 binding activity circulating variant coronavirus coronavirus 2 coronavirus disease COVID-19 cytopathic delta variant domain ELISA enzyme-linked immunosorbent assays humoral IgA IgG IgG antibody IgM immune Immunity Immunoglobulin Infection Live virus median Mild Month Neutralization assay Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody titer P.1 Patient persistent Protein RBD RBD protein respiratory response SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 variant serological response serological response. serum antibody serum sample variant virus was reduced were measured wild-type wild-type SARS-CoV-2 Wuhan-1
[DOI] 10.1093/infdis/jiac099 PMC 바로가기

Hemolytic anemia in COVID-19

코로나19의 용혈성 빈혈

Review

Published on 2022-09-012022-09-11
Journal: Annals of Hematology
[Category] COVID19(2023년), SARS, 치료기술,

[키워드] ACE2 Anemia angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 vaccination auto-Abs autoantibodies autoantibody Autoimmune autoimmune hemolytic anemia caused CD147 Complication comprehensive view contributing to COVID-19 COVID-19 patients COVID-19 treatment cytopathic Early detection early diagnosis erythrocyte global pandemic hemolytic hemolytic anemia highlight increasingly Infection Injury Interaction management Medicine Medicines occur offer outcome point-of-care potential mechanism potential mechanisms Prevent prognostic Protein receptor required SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2. Severe acute respiratory syndrome the SARS-CoV-2 Treatment triggered with COVID-19
[DOI] 10.1007/s00277-022-04907-7 PMC 바로가기 [Article Type] Review

COVID-19 lung disease shares driver AT2 cytopathic features with Idiopathic pulmonary fibrosis

COVID-19 폐 질환은 특발성 폐 섬유증과 드라이버 AT2 세포 변성 기능을 공유합니다

Article

Published on 2022-08-012022-09-12
Journal: EBioMedicine
[Category] COVID19(2023년), MERS, SARS, 바이오마커, 변종, 진단,

[키워드] alveolar Alveolar Type II Alveolar type II pneumocytes analysis analyzed approach artificial Artificial intelligence/machine learning AT2 cells change changes condition COVID COVID-19 Cytokine storm cytopathic Damage-associated transient progenitor (DATP) dataset Deceased determinant develop disease Disease model disease models Diseases DNA damage driven by driver dysfunction effective ER stress ER-stress feature gene expression pattern gene signatures hamsters Host immune response human lung identify Idiopathic pulmonary fibrosis IHC immune response immunohistochemistry Injury interleukin Interleukin 15 (IL15) Interstitial lung diseases IPF lack Like lung Lung disease Lungs molecular monocyte pandemic Pathogenesis Patient patients with IPF Perspective phenotype PPI Prognosis prognostic Program protein-protein interaction pulmonary fibrosis qPCR reversed SARS-CoV-2 SASP senescence Senescence. similarity subject supported therapy transcriptomic Treatment Trigger were used with COVID-19
[DOI] 10.1016/j.ebiom.2022.104185 PMC 바로가기 [Article Type] Article

Emerging Role of ZBP1 in Z-RNA Sensing, Influenza Virus-Induced Cell Death, and Pulmonary Inflammation

Z-RNA 감지, 인플루엔자 바이러스 유발 세포 사멸 및 폐 염증에서 ZBP1의 새로운 역할

Review

Published on 2022-06-282022-09-11
Journal: mBio
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral Apoptosis Cell cell death coronavirus Critical cytopathic death Defense epithelial epithelial cell functional highly pathogenic Host host cell host defense human disease IAV immune sensing immunopathology in vivo Infection Inflammasome Inflammation Inflammatory response Inflammatory responses Influenza influenza A influenza A virus influenza infections influenza viruses Innate Innate immunity innate immunity. Lung infection mechanism necroptosis nucleic acid outbreak Pandemics pathogenic pathogenicity proinflammatory Proinflammatory response promote pulmonary pyroptosis Respiratory illness Respiratory tract infections responses RIPK3 RNA RNA virus role SARS-CoV-2 Signaling triggering understanding viral infections viral strain virus virus Z-RNA ZBP1 zoonotic transmission
[DOI] 10.1128/mbio.00401-22 PMC 바로가기 [Article Type] Review

Sequential dynamics of virological and serological changes in the serum of SARS-CoV-2 infected patients

SARS-CoV-2 감염 환자의 혈청 내 바이러스 및 혈청학적 변화의 순차적 역학

Article

Published on 2022-04-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 진단, 치료기술,

[키워드] acquisition acute respiratory syndrome acute respiratory syndrome coronavirus Admission analyzed antibody Antibody Response Chain Reaction changes in collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Culture cytopathic discharge dropped faster Follow-up highest Hospitalization IgG immune response Immunological response infected patient infected patients investigated knowledge median Mild Mild symptom mild symptoms moderate moderate symptoms neutralization test Neutralizing antibodies neutralizing antibody Patient polymerase chain polymerase chain reaction Protein provide real-time polymerase chain reaction remained respiratory respiratory sample Respiratory samples Ribonucleic acid Sample SARS-CoV-2 SARS-CoV-2 infected patient SARS-CoV-2 spike protein SARS-CoV-2 viral load serological serum serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein surrogate surrogate virus neutralization test Symptoms Test Total undetectable Viral viral culture Viral load Viremia viremia. Virological virus
[DOI] 10.1002/jmv.27518 PMC 바로가기 [Article Type] Article

SARS-CoV-2 detection in primary thyroid sarcoma: coincidence or interaction?

원발성 갑상선 육종에서 SARS-CoV-2 검출: 우연인가 상호작용인가?

Case Reports

Published on 2022-01-052022-09-10
Journal: Journal of Endocrinological Investigation
[Category] COVID19(2023년), MERS, SARS, 치료기술,

[키워드] analyzed Chain Reaction COVID-19 epidemic cytology cytopathic cytoplasmic demonstrated diagnosed diffuse downregulation evaluated expression homolog Hypothesis immunological MDM2 mouse neoplastic neoplastic cells overexpression p53 pathway Patient polymerase chain polymerase chain reaction real-time polymerase chain reaction retrieved Sarcoma SARS-CoV-2 SARS-CoV-2 detection sequence specimen Spread Subacute thyroiditis synergistic Thyroid thyroid dysfunction Thyroiditis Tumor tumor cell tumor cells tumor growth turn Vero E6 Vero E6 cell VERO E6 cells Viral viral particle Viral particles viral persistence Whole-genome sequence
[DOI] 10.1007/s40618-021-01722-1 PMC 바로가기 [Article Type] Case Reports

Cytopathological Findings in Bronchoalveolar Lavage from Patients with COVID-19

Article

Published on 2022-01-012022-11-15
Journal: Acta cytologica
[Category] 진단,

[키워드] addition addressed alveolar Analysis Atypical BAL bronchial cell Bronchoalveolar lavage Cell cellular change changes Characteristics clearance clinically collected COVID-19 cytopathic Cytopathic effect Cytopathological finding. cytoplasmic described evaluated finding increase in Inflammatory information lavage leukocyte lymphocyte Macrophage macrophages malignancy molecular multinucleated giant cell multinucleated giant cells Nasopharyngeal swab neutrophilic nuclear nuclear chromatin nuclei pathological change pathological changes patients patients with COVID-19 Peripheral blood pneumocyte Pneumonia reactive reported Research respiratory tract suspected patient virus with COVID-19
[DOI] 10.1159/000525339 PMC 바로가기

The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ

Research Article

Published on 2021-12-222022-10-30
Journal: mSphere
[Category] Coronavirus,

[키워드] Air-liquid interface airway epithelium ALI-REC Alpha Antiviral basal cells Betacoronavirus CCL2 CCL5 Cell culture cell cultures cells change chemokine chemokines ciliated cells coronavirus Culture CXCL10 CXCL8 Cytokines cytopathic disease Donor driving epithelia epithelial lining evaluated expression expression level Gene Expression goblet cells homeostasis IFN-λ1 IFN-stimulated gene IFN-λ IFN-λ1 IL-1β IL-6 IL-8 in vitro in vivo Including Increased infect Infection innate immune gene innate immune response Innate immunity innate response interleukin-1β investigated modulation molecular mechanism morphologically Necrosis Neonatal neurotropic OAS1 outcome pattern PHEV primary site Proinflammatory cytokine proliferative Recognition replicate replicated respiratory respiratory epithelia respiratory epithelial cell resulting RIG Stat1 tissue TLR TLR3 TLR7 TNF-α tracheal transcription factor Transcriptional upregulation triggered turn upper respiratory tract upregulation virus vomiting
[DOI] 10.1128/mSphere.00820-21 PMC 바로가기 [Article Type] Research Article

Anti-SARS-CoV-2 Immunoglobulin Isotypes, and Neutralization Activity Against Viral Variants, According to BNT162b2-Vaccination and Infection History

BNT162b2-백신 접종 및 감염 이력에 따른 Anti-SARS-CoV-2 면역글로불린 아이소타입 및 바이러스 변이체에 대한 중화 활성

Immunology

Published on 2021-12-172022-09-11
Journal: Frontiers in Immunology
[Category] SARS, 변종, 진단, 치료기술, 치료법,

[키워드] activity Against anti-RBD Anti-RBD IgG antigen-specific antibody assays B.1 bead BNT162b2 BNT162b2 vaccine both group both groups coronavirus COVID-19 COVID-19 disease COVID‐19 cytopathic delta variant Delta variants disease domain dose expression pattern Fluorescence followed by Gamma highest history IgA IgG IgG levels IgM immunoassay Immunoglobulin immunoglobulins individual maximum mRNA vaccine multiplex immunoassay naïve neutralization Neutralization assay Neutralizing activity neutralizing capacity neutralizing titers Nucleocapsid proteins plasma post-symptom onset provided RBD Result SARS-CoV-2 SARS-CoV-2 antigen Serological assay single vaccine subject subjects suggested Support symptom onset three groups vaccination Vaccine variants Vero E6 Viral Viral antigen was determined
[DOI] 10.3389/fimmu.2021.793191 PMC 바로가기 [Article Type] Immunology